作者: Taku Tamura , James H. Cormier , Daniel N. Hebert
DOI: 10.1016/J.TIBS.2008.04.013
关键词:
摘要: Proteins that improperly mature in the endoplasmic reticulum (ER) are dislocated to cytoplasm for proteasome-mediated destruction. A recent study provides insight into incompletely understood processes selection and targeting of aberrant proteins ER-associated protein degradation. The identification ER chaperones GRP94 BiP as binding partners mannose-binding OS-9 XTP3-B, indicates these complexes bind direct them Hrd1 dislocation ubiquitylation complex membrane.