Cation metabolism during propofol sedation with and without EDTA in patients with impaired renal function.

摘要: Objective: To compare the effects of propofol with and without disodium edetate (EDTA) on cation metabolism in intensive care unit (ICU) patients renal insufficiency who received or plus EDTA (propofol EDTA) for sedation mechanical ventilation. Design: Double-blind, randomised, multicentre study. Setting: Medical surgical ICUs from 5 hospitals. Patients: Thirty-nine ICU acute chronic impairment expected to require at least 24 hours continuous respiratory failure necessitating Interventions: Propofol administered by intravenous infusion. Measurements Results: The depth sedation, as measured Modified Ramsay Sedation Scale, was similar 2 groups, when adjusted dosing differences. amount required maintain adequate decreased both groups compared requirements normal function. levels were elevated baseline groups. In group, increased further 20 % but below 48 after sedation. during remained Patients hypocalcaemic hyperphosphataemic low 1,25-dihydroxyvitamin D parathyroid hormone (PTH) levels. Other than a slight difference ionised serum calcium 4 h start there no significant differences observed between two There PTH over time effect function either group. Conclusions: results this study suggest that adding does not adversely affect homeostasis used insufficiency. Although receive EDTA, increase appear be clinically significant, return within discontinuing efficacy also appears comparable these patients.