Miktoarm Star Polymer Based Multifunctional Traceable Nanocarriers for Efficient Delivery of Poorly Water Soluble Pharmacological Agents

摘要: A versatile methodology to develop an inherently fluorescent and thus traceable multifunctional nanodelivery platform based on miktoarm polymers is reported. Miktoarm stars containing covalently linked tetraiodofluorescein dye, polyethylene glycol, polycaprolactone self-assemble into micelles, integrate multiple functions including tags for imaging, a hydrophobic core drug incorporation, hydrophilic corona micelle stabilization. Curcumin, pleiotropic but very poorly water-soluble drug, loaded these micelles with efficiency of 25-60 wt%. It leads 25 000-fold increase in its aqueous solubility, sustained release over period 7 d. These are rapidly internalized murine J774A.1 macrophages, accumulated discrete cellular compartments, whereas the free physically encapsulated dye diffused cytoplasm. Curcumin-loaded reduce lipopolysaccharide-induced nitric oxide release. The studies establish star nanocarriers as highly efficient tracking their fate expanding scope pharmacological agents limited utility experimental medicine.