Influence of diagnostic and therapeutic doses on thyroid remnant ablation rates.

摘要: Radioiodine ablation of thyroid tissue after subtotal thyroidectomy has been shown to decrease recurrence in certain subsets patients with well-differentiated cancer. In a substantial percentage cases (20-30%), initial the remnant fails, necessitating second treatment. The factors associated failure are not fully understood. particular, it is whether use doses higher than 3.70 GBq would result any additional benefit, or there 'stunning' effect diagnostic dose 131I on subsequent rate. A retrospective analysis was performed all (n=389) cancer treated at our institution between 1992 and 2001. Remnant success determined by whole-body radioiodine scan. following factors, thought be ablation, were studied logistic regression analysis: age, gender, tumour histology, stage, pre-therapy neck uptake 131I, dose, time therapeutic (T1), administration first follow-up scan (T2) thyroid-stimulating hormone (TSH) level measured therapy. Follow-up scans available 214 patients. We found no association TSH level, uptake, successful ablation. only variable (odds ratio, 1.96 per 1.85 increment; 95% confidence interval, 1.11-3.46). Our results confirm presence significant failures (24.4%) despite high ablative (3.70-7.40 GBq). Higher rates even when administered more advanced stages. Using protocol, failure.