Bioavailability of a natural isomer mixture compared with synthetic all-trans beta-carotene in human serum.

摘要: The unicellular alga Dunaliella bardawil was shown previously to contain very high concentrations of beta-carotene composed about equal amounts the all-trans and 9-cis isomers, which differ in their physicochemical features antioxidative activity. uptake alpha- beta-carotenes, oxycarotenoids, other lipophilic substances from a basal diet supplemented with synthetic or dry D. power studied humans. Subjects were given daily 40 mg beta-carotene, natural, for relatively short period 14 d. Serum analyses at end this detected mainly lesser extent alpha-carotene, but not beta-carotene. Retinol increased by diet. A amount oxidized dienic, polar products exhibited HPLC predominantly sera placebo groups strong, ultraviolet absorbance peaks 232 nm. preferential serum absorption over parallel appearance concentration dienic supplementation compared low serum-oxidized natural source, suggests that acts as an vivo antioxidant more efficiently than does