Mometasone furoate topikal menurunkan kadar IL3, IL9-serum dan jumlah eosinofil mukosa hidung penderita rinitis alergi

作者: Agus Kurniawan , Stephani Linggawan , Endang Retnoningsih , Rus Suheryanto , Edi Handoko

DOI: 10.32637/ORLI.V43I2.70

关键词:

摘要: Latar belakang : Rinitis alergi merupakan inflamasi kronis mukosa hidung yang diperantarai oleh IgE, sering berhubungan dengan banyak ko-morbid dan berdampak pada kualitas hidup. Interleukin (IL)3 IL9 berperan dalam proses pembentukan eosinofil, sedangkan eosinofil diketahui berperan penting dalam menyebabkan keluhan hidung buntu kerusakan epitel penderita rinitis alergi. Mometasone furoate merupakan kortikosteroid topikal generasi terbaru jarang efek samping. Tujuan Penelitian ini bertujuan mengetahui perubahan kadar IL3, IL9-serum, jumlah sesudah pemberian semprot mometasone Metode observasional analitik melibatkan 38 diberi selama 2 minggu dosis 200 µg/hari. Kadar diukur sebelum perlakuan. Hasil Data dianalisis uji t-berpasangan Wilcoxon. menurun secara bermakna (p <0,001) minggu. Kesimpulan terbukti berpengaruh terhadap penurunan lebih lanjut diperlukan untuk pengaruh sitokin lain alergi, pengukuran IL3 IL9-mukosa hidung, hubungan IL9-serum. Kata kunci IL9, furoate.

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