Cream Formulation Impact on Topical Administration of Engineered Colloidal Nanoparticles

摘要: In order to minimize the impact of systemic toxicity drugs in treatment local acute and chronic inflammatory reactions, achievement reliable efficient delivery therapeutics in/through skin is highly recommended. While use nanoparticles now an established practice for drug intravenous targeted delivery, their transdermal penetration still poorly understood this important administration route remains almost unexplored. present study, we have synthesized magnetic (iron oxide) (MNP) coated with amphiphilic polymer, developed a water-in-oil emulsion formulation topical compared routes same deposited as colloidal suspension. Transmission scanning electron microscopies provided ultrastructural evidence that (PMNP) cream allowed through all layers controllable kinetics suspension formulation. addition preferential follicular pathway, also intracellular intercellular were involved. PMNP crossed quantified by inductively coupled plasma mass spectrometry. The obtained data suggests combining character improves intradermal nanoparticles. living mice via aqueous resulted nanoparticle capture phagocytes migration draining lymph nodes, favored uptake analyzed dermis cell types, including hematopoietic non-hematopoietic. Unlike suspension, maintenance dermal architecture avoiding dispersion nodes afferent lymphatics.