Differential Expression of E-Cadherin and High Molecular Weight Cytokeratin in Invasive Lobular and Ductal Breast Carcinoma

作者: Ali S. Sawan

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摘要: This study included 62 breast biopsy cases; 39 invasive carcinoma, 11 non-invasive carcinoma cases and 12 benign lesions. Immunohistochemical revealed; ductal mucinous epithelial component in metaplastic lesions were positive to E-cadherin. All lobular carcinomas, sarcomatoid of neuroendocrine totally negative However, 45.5% all plus showed reaction high molecular weight cytokeratin. Cases situ Previous results concluded that immunohistochemical E-cadherin expression was recommended as a tool differentiate between challenging it has no role differentiating hyperplastic from situ. In contrast, cytokeratin discriminating thus can hyperplasia

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