Serum 25-hydroxyvitamin D measurement in a large population survey with statistical harmonization of assay variation to an international standard.

作者: Elina Hyppönen , Steve Turner , Phillippa Cumberland , Christine Power , Ian Gibb

DOI: 10.1210/JC.2007-1279

关键词:

摘要: Context: An automated application of Immunodiagnostic Systems Limited (IDS) OCTEIA 25-hydroxyvitamin D [25(OH)D] enzyme immunoassay was developed for analyses 25(OH)D in more than 7000 participants the 1958 cohort. Variation between assays hampers between-study comparisons and definition relevant cutoffs hypovitaminosis D. Objective: The objective study to evaluate importance assay variation on estimated prevalence assess use statistical harmonization overcome observed differences. Design: Agreement were performed two commercial (IDS Diasorin RIA), with validation using performance data from Vitamin External Quality Assessment Scheme (DEQAS). Setting: conducted England, Scotland, Wales. Participants: Members British birth cohort participated study. Main Outcome Measures: measured both by IDS RIA 78...

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