Regulation of tight junction proteins and bladder epithelial paracellular permeability by an antiproliferative factor from patients with interstitial cystitis.
作者： CHEN-OU ZHANG , JIAN-YING WANG , KRISTOPHER R. KOCH , SUSAN KEAY
DOI: 10.1097/01.JU.0000180417.11976.99
关键词:
摘要: ABSTRACTPurpose: Previous reports have suggested that the bladder epithelial barrier may be compromised in interstitial cystitis (IC). Antiproliferative factor (APF) is a small glycoprotein made specifically by cells patients with IC induces changes expression of certain cell proteins and profoundly inhibits growth. Therefore, we confirmed increased permeability decreased tight junction formation monolayers grown from biopsies compared to normal controls. We then determined effect APF on proteins.Materials Methods: Permeability was measuring 14C-mannitol 3H-inulin flux between confluent Transwell culture plates (Corning, Corning, New York). Tight assessed immunofluorescence microscopy specific pr...
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