Shared Brain Connectivity Issues, Symptoms, and Comorbidities in Autism Spectrum Disorder, Attention Deficit/Hyperactivity Disorder, and Tourette Syndrome.
作者： Janet K. Kern , David A. Geier , Paul G. King , Lisa K. Sykes , Jyutika A. Mehta
关键词:
摘要: Abstract The prevalence of neurodevelopmental disorders, including autism spectrum disorder (ASD), attention deficit/hyperactivity (ADHD), and Tourette syndrome (TS), has increased over the past two decades. Currently, about one in six children United States is diagnosed as having a disorder. Evidence suggests that ASD, ADHD, TS have similar neuropathology, which includes long-range underconnectivity short-range overconnectivity. They also share symptomatology with considerable overlap their core associated symptoms frequent comorbid conditions. Consequently, it apparent diagnoses belong to broader illness. Biologically, overconnectivity are plausibly related neuronal insult (e.g., neurotoxicity, neuroinflammation, excitotoxicity, sustained microglial activation, proinflammatory cytokines, toxic exposure, oxidative s...
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