Colistin as a salvage therapy for nosocomial infections caused by multidrug-resistant bacteria in the ICU.
作者： Hatem Kallel , Mabrouk Bahloul , Leila Hergafi , Malek Akrout , Wajdi Ketata
DOI: 10.1016/J.IJANTIMICAG.2006.07.008
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摘要: Abstract The objective of this study was to determine the efficacy systemic colistin therapy in treatment nosocomial infections caused by multidrug-resistant Acinetobacter baumannii or Pseudomonas aeruginosa and related adverse events. We prospectively studied 78 A. P. that were treated with colistin. sites infection pulmonary (78.2%), urinary tract (7.7%), primary bloodstream (11.5%) meningitis (2.6%). mean daily dose 5.5 ± 1.1 MU/day (range 2–9 MU/day) duration 9.3 ± 3.8 days 5–21 days). A favourable clinical response occurred 60 cases (76.9%). Renal failure only seven cases. conclude can be a safe effective salvage therapeutic option for .
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