Convergent Strategy Towards the Synthesis of Restricted Analogues of Peloruside A
作者： Nicolas Zimmermann , Pierre Pinard , Bertrand Carboni , Pascal Gosselin , Catherine Gaulon-Nourry
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摘要: A rapid convergent strategy to access unsaturated analogues of peloruside has been demonstrated. This is depicted as an original C11-C12 aldol connection between a C12-C20 ketone fragment and C2-C11 pyran bearing aldehyde function, with high yield good level diastereoselectivity. The desired macrocycle was obtained by late-stage ring closing metathesis reaction.
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