Matrix metalloproteinase-2: the forgotten enzyme in aneurysm pathogenesis.
作者： M. THOMPSON , G. COCKERILL
关键词:
摘要: The pathogenesis of abdominal aortic aneurysm (AAAs) involves progressive cycles proteolysis and inflammation, the product driving subsequent inflammation. Little is yet known about initiating events. We review specific literature examining possibility that MMP-2 may be initial catalyst. Histologically, elastolysis one earliest observable events in genesis. Matrix metalloproteinase-2 (MMP-2), as dominant gelatinase differentially expressed aneurysmal tissue cells derived from aneurysms, would a good candidate. report results vivo vitro experiments, which lend support to importance an initiator.
harvard.edu
sci-hub.se 参考文章(11)
Mathew Crowther, Stephen Goodall, J.Louise Jones, Peter R.F. Bell, Matthew M. Thompson, Increased matrix metalloproteinase 2 expression in vascular smooth muscle cells cultured from abdominal aortic aneurysms Journal of Vascular Surgery. ,vol. 32, pp. 575- 583 ,(2000) , 10.1067/MVA.2000.108010
William D. McMillan, Bruce K. Patterson, Richard R. Keen, William H. Pearce, In situ localization and quantification of seventy-two – kilodalton type IV collagenase in aneurysmal, occlusive, and normal aorta Journal of Vascular Surgery. ,vol. 22, pp. 295- 305 ,(1995) , 10.1016/S0741-5214(95)70144-3
Valerie Davis, Raisa Persidskaia, Lisa Baca-Regen, Yoshifumi Itoh, Hideaki Nagase, Yuri Persidsky, Anuja Ghorpade, B. Timothy Baxter, Matrix Metalloproteinase-2 Production and Its Binding to the Matrix Are Increased in Abdominal Aortic Aneurysms Arteriosclerosis, Thrombosis, and Vascular Biology. ,vol. 18, pp. 1625- 1633 ,(1998) , 10.1161/01.ATV.18.10.1625
Stephen Goodall, Mat Crowther, Peter R. Bell, Matt M. Thompson, The association between venous structural alterations and biomechanical weakness in patients with abdominal aortic aneurysms. Journal of Vascular Surgery. ,vol. 35, pp. 937- 942 ,(2002) , 10.1067/MVA.2002.122877
B.Timothy Baxter, Valerie A. Davis, David J. Minion, Yi Ping Wang, Thomas G. Lynch, Bruce M. McManus, Abdominal aortic aneurysms are associated with altered matrix proteins of the nonaneurysmal aortic segments. Journal of Vascular Surgery. ,vol. 19, pp. 797- 803 ,(1994) , 10.1016/S0741-5214(94)70004-4
Tim Freestone, Robert J. Turner, Andrew Coady, Dan J. Higman, Roger M. Greenhalgh, Janet T. Powell, Inflammation and Matrix Metalloproteinases in the Enlarging Abdominal Aortic Aneurysm Arteriosclerosis, Thrombosis, and Vascular Biology. ,vol. 15, pp. 1145- 1151 ,(1995) , 10.1161/01.ATV.15.8.1145
M. Crowther, S. Goodall, J. L. Jones, P. R. F. Bell, M. M. Thompson, Localization of matrix metalloproteinase 2 within the aneurysmal and normal aortic wall. British Journal of Surgery. ,vol. 87, pp. 1391- 1400 ,(2002) , 10.1046/J.1365-2168.2000.01554.X
S. Goodall, K.E. Porter, P.R. Bell, M.M. Thompson, Enhanced invasive properties exhibited by smooth muscle cells are associated with elevated production of MMP-2 in patients with aortic aneurysms. European Journal of Vascular and Endovascular Surgery. ,vol. 24, pp. 72- 80 ,(2002) , 10.1053/EJVS.2002.1675
Anthony S. Ward, Aortic Aneurysmal Disease Archives of Surgery. ,vol. 127, pp. 990- 991 ,(1992) , 10.1001/ARCHSURG.1992.01420080124021
Stephen Goodall, Mat Crowther, David M. Hemingway, Peter R. Bell, Matt M. Thompson, Ubiquitous Elevation of Matrix Metalloproteinase-2 Expression in the Vasculature of Patients With Abdominal Aneurysms Circulation. ,vol. 104, pp. 304- 309 ,(2001) , 10.1161/01.CIR.104.3.304