Emergence of Mild Cognitive Impairment in Late Middle-Aged Adults in the Wisconsin Registry for Alzheimer's Prevention

摘要: Aim: It is difficult to reliably detect the earliest signs of Alzheimer's disease (AD)-associated cognitive impairment. Our aim was compare 3 psychometric methods identifying amnestic mild impairment (aMCI) in a middle-aged longitudinal cohort enriched for AD risk. Methods: Wisconsin Registry Prevention (WRAP) participants with waves assessment over approximately 6 years were coded as meeting each aMCI definitions: (a) ‘aMCI standard-baseline' used published norms establish cutoffs baseline performance; (b) robust-baseline' applied WRAP-specific robust baseline, and (c) robust-multiwave' these across assessment. Each group compared cognitively healthy subset. Results: Half standard-baseline one third robust-baseline reverted normal ranges at follow-up. Only robust-multiwave method had an × age interaction showing significantly worse age-related memory declines Conclusion: Both cross-sectional showed instability time, many reverting performance after baseline. The multiwave approach identified who progressive visits. Being able decline late middle critical step improving prevention efforts.