Role of Catecholamines in the Development of Tolerance to Barbiturates and Ethanol
作者： Boris Tabakoff , R. F. Ritzmann , Paula L. Hoffman
DOI: 10.1007/978-1-4615-9038-5_11
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摘要: The destruction of noradrenergic systems in brain by administration 6-hydroxydopamine prior to chronic ethanol treatment prevented the development tolerance ethanol. Animals pretreated with 6-hydroxy dopamine also showed no cross barbiturates. Destruction barbiturates partially pentobarbital. 6-Hydroxydopamine pretreatment had little effect on signs physical dependence produced possible dissociation and role these phenomena is discussed.
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