Morpho-Regulation of Ectodermal Organs

摘要: Ectodermal organs are composed of keratinocytes organized in different ways during induction, morphogenesis, differentiation, and regenerative stages. We hypothesize that an imbalance fundamental signaling pathways should affect multiple ectodermal a spatio-temporal-dependent manner. produced K14-Noggin transgenic mouse to modulate bone morphogenic protein (BMP) activity test the extent this hypothesis. observed thickened skin epidermis, increased hair density, altered types, faster anagen re-entry, formation compound vibrissa follicles. The eyelid opening was smaller ectopic cilia formed at expense Meibomian glands. In distal limb, there were agenesis hyperpigmentation claws, interdigital webbing, reduced footpads, trans-differentiation sweat glands into hairs. size external genitalia both sexes, but they remained fertile. conclude modulation BMP can number by acting induction stages, influence shape morphogenesis change phenotypes differentiation facilitate new growth regeneration Therefore organogenesis, antagonists produce spectrum stage-dependent manner adjusting level activity. distinction between phenotypic variations pathological changes is discussed.