NCL-CD10–270: A New Monoclonal Antibody Recognizing CD10 in Paraffin-Embedded Tissue
作者： Gary G. McIntosh , Andrew J. Lodge , Peter Watson , Andrew G. Hall , Katrina Wood
DOI: 10.1016/S0002-9440(10)65253-4
关键词:
摘要: CD10 (CALLA) antigen is expressed in a wide variety of epithelial and nonepithelial tissues, but its most significant application the diagnosis classification certain types malignant lymphoma leukemia. high percentage cases acute lymphoblastic leukemia (ALL), follicular lymphoma, Burkitt's some hematopoietic tumors. Although not lineage specific, expression widely used to define subgroups within B-ALL useful tool for detecting presence leukemic blasts bloodstream. Currently available monoclonal antibodies have been found be effective only fresh-frozen tissue techniques such as flow cytometry. We recombinant protein corresponding whole generate antibody that paraffin-embedded sections. this assay on range normal pathological tissues. Strong staining was seen lymphoid germinal centers, renal tubules, glomeruli, syncytiotrophoblast, hepatic parenchymal canaliculi, B-lineage ALL, follicle center cell proportion large-B-cell lymphoma. believe will value characterization particular differential small-B-cell subtyping leukemia, well investigation significance other
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