Gene Therapy for Sarcoma
作者： Keila E. Torres , Raphael E. Pollock
DOI: 10.1007/978-1-4419-6102-0_14
关键词:
摘要: Soft tissue sarcomas are a group of potentially devastating malignancies. Despite multidisciplinary treatment combining surgery, radiation therapy, and chemotherapy, the overall prognosis for sarcoma patients remains poor. Very few chemotherapeutic agents with meaningful efficacy: toxicity ratios available, development novel therapeutics will be critical if this currently unacceptable is to improved. Much exciting progress in genetic profiling molecular identification constituent oncogenes protein products has recently occurred, which ultimately enable targeted therapies. In chapter, we discuss major advances cytogenetics importance signatures diagnosis treatment. an attempt create better treatments cancers several strategies have evolved administer therapeutic genes that inactivate oncogenes, restore tumor-suppressor genes, enhance native immune response. We explore some promising initial data regarding gene delivery systems, such as isolated limb perfusion may useful technique delivering growth-suppressing constructs into soft sarcomas.
springer.com
sci-hub.st 参考文章(101)
C. Cordon-Cardo, D. Pollack, M. R. Oliva, Chromosome 17 abnormalities and TP53 mutations in adult soft tissue sarcomas. American Journal of Pathology. ,vol. 145, pp. 345- 355 ,(1994)
Nawa G, Miyoshi Y, Nakamura Y, Iwao K, Ochi T, Yoshikawa H, Frequent mutations in the beta-catenin gene in desmoid tumors from patients without familial adenomatous polyposis. Oncology Research. ,vol. 10, pp. 591- 594 ,(1998)
D. Kotiligam, Dina Lev, Alexander Lazar, Raphael E. Pollock, Desmoid tumor: a disease opportune for molecular insights Histology and Histopathology. ,vol. 23, pp. 117- 126 ,(2008) , 10.14670/HH-23.117
M. Alberghini, G. Magagnoli, G. Gamberi, C. Ghinelli, M. S. Benassi, L. Pazzaglia, F. Bertoni, M. Serra, F. Ponticelli, Paolo Ragazzini, C. Ferrari, P. Picci, Amplification of CDK4, MDM2, SAS and GLI genes in leiomyosarcoma, alveolar and embryonal rhabdomyosarcoma. Histology and Histopathology. ,vol. 19, pp. 401- 411 ,(2004) , 10.14670/HH-19.401
Susanne V. Allander, Peter B. Illei, Yidong Chen, Cristina R. Antonescu, Mike Bittner, Marc Ladanyi, Paul S. Meltzer, Expression profiling of synovial sarcoma by cDNA microarrays: association of ERBB2, IGFBP2, and ELF3 with epithelial differentiation. American Journal of Pathology. ,vol. 161, pp. 1587- 1595 ,(2002) , 10.1016/S0002-9440(10)64437-9
Raphael E. Pollock, Aiqing Lang, Dihua Yu, Lee M. Ellis, Lianglin Zhang, Mei Hu, Shunbin Xiong, Wild-type p53 suppresses angiogenesis in human leiomyosarcoma and synovial sarcoma by transcriptional suppression of vascular endothelial growth factor expression. Cancer Research. ,vol. 60, pp. 3655- 3661 ,(2000)
Ming Tan, Raphael Pollock, Aiqing Lang, Dihua Yu, Tong Ge, Dantong Sun, Wild-type p53 and a p53 temperature-sensitive mutant suppress human soft tissue sarcoma by enhancing cell cycle control. Clinical Cancer Research. ,vol. 4, pp. 1985- 1994 ,(1998)
J. Kaiser, CLINICAL RESEARCH: Death Prompts a Review of Gene Therapy Vector Science. ,vol. 317, pp. 580- 580 ,(2007) , 10.1126/SCIENCE.317.5838.580
Thomas W. Dubensky, Margaret A. Liu, Jeffrey B. Ulmer, Delivery systems for gene-based vaccines. Molecular Medicine. ,vol. 6, pp. 723- 732 ,(2000) , 10.1007/BF03402189
Olav Engebraaten, Eivind Hovig, Øystein Fodstad, Eugene Lukanidin, Vivi Ann Flørenes, Gunhild Mari Mælandsmo, Martina Skrede, Mariam Grigorian, Ola Myklebost, Kevin J. Scanlon, Reversal of the in Vivo Metastatic Phenotype of Human Tumor Cells by an Anti-CAPL (mts1) Ribozyme Cancer Research. ,vol. 56, pp. 5490- 5498 ,(1996)