Bacterial vaginosis and HIV acquisition: A meta-analysis of published studies

摘要: Bacterial vaginosis (BV) is the most frequent type of vaginitis in women reproductive age [1–3]. BV an imbalance ecology normal vaginal flora [4] that characterized by depletion lactobacilli [3], and proliferation anaerobic bacteria such as Gardnerella vaginalis, Morbilincus species, Prevotella Mycoplasma hominis recently identified Atopobium vaginae [2, 5–7]. It often manifests clinically a pH >4.5, presence thin whitish homogenous discharge, detection “clue” cells amine odor after addition 10 percent potassium hydroxide [8, 9]. has been shown to increase risk adverse gynecological obstetrical outcomes preterm delivery[10, 11] pelvic inflammatory disease (PID) upper genital tract infections [12–14]. However, effect on HIV infection not clearly quantified. The magnitude association between varied epidemiological studies, ranging from absence any association[15] near four-fold odds being infected among BV-positive compared BV-negative [16]. estimated be prevalent particularly countries with high prevalence [2]. If confirmed infection, treatment could meaningful intervention prevent acquisition. In 2001 review role sexually transmitted diseases acquisition, Rottingen et al was associated 40% based analysis two studies[17]. Obtaining precise updated estimate strength published studies useful predicting potential impact control incidence rates population. This prediction also more accurate if factors modify were identified. This paper aims systematically all infection. Estimates are presented for both analyzed modification factors, publication bias, heterogeneity study results.