New cell cycle-regulated genes in the yeast Saccharomyces cerevisiae.

摘要: Primary carcinogenic changes involve mutations in genes which contribute to the ordered events that control eucaryotic cell cycle. It has been demonstrated many protooncogenes take part regulation of growth. Pradl, for instance, identified as cyclin Dl. Myc is involved early cycle while p53, one growing number tumor suppressors, blocks Gl response DNA damage. These proteins interfere with certain elements and cause either induction or repression specific regulatory events. However, when mutated these regulators may be unable fulfill their proper function can then lead inappropriate progression. This result death transformation from quiescence uncontrolled proliferation. Thus, investigation will a better understanding molecular malignant