A hypothetical model for predicting the toxicity of high aspect ratio nanoparticles (HARN)

摘要: The ability to predict nanoparticle (dimensional structures which are less than 100 nm in size) toxicity through the use of a suitable model is an important goal if nanoparticles be regulated terms exposures and toxicological effects. Recently, with high aspect ratio has been put forward by consortium scientists. High (HARN) platform that relates physical dimensions HARN (specifically length diameter ratio) biopersistence their biological environments. Potentially, this great public health economic importance, as it can used tool not only activity but classify various fibrous nanoparticles, without need carry out time-consuming expensive toxicology studies. However, currently hypothetical nature based solely on drawing similarities its dimensional geometry asbestos synthetic vitreous fibres. aim review two-fold: (a) present findings from past literature, physicochemical property pathogenicity bioassay testing (b) identify some challenges future research steps crucial before accepted predictive model. By presenting what done, we able scientific directions needed for gain acceptance. Our recommendations includes to: accurately link data corresponding assay data, reference standards standardised protocols, develop better tools/techniques characterisation, (c) ways monitoring workplace, (d) reliably measure dose exposure levels, order support epidemiological