REG Iα gene expression is linked with the poor prognosis of lung adenocarcinoma and squamous cell carcinoma patients via discrete mechanisms.
作者： MICHITAKA KIMURA , HIROSHI NAITO , TAKASHI TOJO , ASAKO ITAYA-HIRONAKA , YOSHIKO DOHI
DOI: 10.3892/OR.2013.2739
关键词:
摘要: The aim of the present study was to evaluate effects REG Iα and Iβ genes on lung cancer cell lines, thereafter, expression family (REG Iα, Iβ, III, HIP/PAP IV) in relation patient prognosis evaluated. Lung adenocarcinoma (AD) squamous carcinoma (SCC) lines expressing or (HLC-1 Iα/Iβ EBC-1 Iα/Iβ) were established, number, invasive activity, anchorage-independent growth compared with these variables control cells. levels evaluated by real-time RT-PCR surgically resected cancers, disease-specific survival (DSS) curves generated. HLC-1 line showed significant increases number cells activity as Except for gene, other observed samples; however, DSS significantly worse only stage I patients who positive than negative expression. AD SCC different vitro study, a correlation between noted vivo study. Therefore, overexpression is risk factor poor caused discrete mechanisms patients.
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