The Effectiveness of the Nicotine Patch for Smoking Cessation

摘要: Objective —To estimate the overall efficacy and optimal use of nicotine patch for treating tobacco dependence. Data Sources. —Nicotine studies published through September 1993, identified MEDLINE, Psychological Abstracts, Food Drug Administration new drug applications. Study Selection. —Double-blind, placebo-controlled 4 weeks or longer with random assignment subjects, biochemical confirmation abstinence, subjects not selected on basis specific diseases (eg, coronary artery disease). Extraction. — Pooled abstinence rates combined odds ratios (ORs) at end treatment 6-month follow-up were examined in terms type (16-hour vs 24-hour), duration, dosage reduction (weaning), counseling format (individual group), intensity adjuvant behavioral counseling. Synthesis. —Across 17 (n=5098 patients) meeting inclusion criteria, active 27% (vs 13% placebo) 22% 9% 6 months. The ORs placebo 2.6 3.0 was superior to regardless weaning, format, intensity. 16-hour 24-hour patches appeared equally efficacious, extending beyond 8 did appear increase efficacy. pooled data showed that intensive had a reliable but modest positive impact quit rates. Conclusions. —The is an effective aid quitting smoking across different patch-use strategies. Active more than twice as likely individuals wearing patch, this effect present both high low intensities cessation has potential improve public health significantly. ( JAMA . 1994;271:1940-1947)