Methods and apparatus for the conditioning of ligament replacement tissue

摘要: Apparatus and methods are disclosed for maturing an elongate replacement tissue construct in vitro prior to use of the vivo as, example, a ligament. The is seeded with specific cells, exposed maturation fluid, subjected selected forces, which can include longitudinal stress (i.e. stressing along its axis). disposed chamber that confines fluid introduction tissue. A first mounting element couples end biopolymer second such extends axis, force applied at least one elements longitudinally foregoing apparatus intended provide more readily integrable vivo, i.e., degrades, regenerates remodels produce durable functional