Oral versus topical Ibuprofen for chronic knee pain: a prospective randomized pilot study.
作者： Robert L. Tiso , Sarani Tong-Ngork , Katherine L. Fredlund
关键词:
摘要: BACKGROUND Topical ibuprofen provides an alternative treatment to oral for the of chronic knee pain. OBJECTIVE To compare efficacy topical versus in pain treatment. STUDY DESIGN Prospective, randomized, unblinded pilot study. SETTING A private management practice. METHODS Twenty patients received either tablets 3 times daily (2400 mg total) or 4% gel 4 (320 2 weeks. Subjects completed Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index, Medical Outcomes Study 12-Item Short Form (SF-12v2) Health Survey, a satisfaction questionnaire. RESULTS Comparison WOMAC SF-12v2 mean changes from baseline showed no differences between groups. Patient study convenience were rated equivalently Within group, significant improvements (P < 0.05) experienced Pain scores weeks (-82.6, -158.3 -6.8), Stiffness one week (-25.3, -50.0 -0.6) (-47.8, -95.7 0.1), Physical Function (-175.9, -348.6 -3.2) (-312.1, -580.5 -43.7), patient (-342.6, -638.1 -47.1) (-323.2, -637.1 -9.2). LIMITATIONS As this was preliminary investigation, sample size 20 subjects is limitation CONCLUSION Treatment with provided comparable clinical as
researchgate.net 
sci-hub.st 参考文章(45)
M Whitefield, J Machen, Efficacy of a proprietary ibuprofen gel in soft tissue injuries: a randomised, double-blind, placebo-controlled study. International Journal of Clinical Practice. ,vol. 56, pp. 102- 106 ,(2002)
F. Sopena, A. Lanas, How to advise aspirin use in patients who need NSAIDs. Current Pharmaceutical Design. ,vol. 13, pp. 2248- 2260 ,(2007) , 10.2174/138161207781368837
Wilkinson Fe, Spitznagel W, Kaiser Rr, Ouwerkerk M, Kleinbloesem Ch, Pharmacokinetics and bioavailability of percutaneous ibuprofen. Drug Research. ,vol. 45, pp. 1117- 1121 ,(1995)
F E Wilkinson, R R Kaiser, M Dominkus, K Chlud, M Nicolakis, R Kotz, Comparison of tissue and plasma levels of ibuprofen after oral and topical administration. Drug Research. ,vol. 46, pp. 1138- 1143 ,(1996)
Pamela L Cross, , Deborah Ashby, Geoff Harding, Enid M Hennessy, Louise Letley, Suzanne Parsons, Anne E Spencer, Martin Underwood, TOIB Study. Are topical or oral ibuprofen equally effective for the treatment of chronic knee pain presenting in primary care: a randomised controlled trial with patient preference study. [ISRCTN79353052] BMC Musculoskeletal Disorders. ,vol. 6, pp. 55- 55 ,(2005) , 10.1186/1471-2474-6-55
Ute Vögtle-Junkert, Michael Fischer, Frank Schreyger, Karel Trnavský, Efficacy and safety of 5% ibuprofen cream treatment in knee osteoarthritis. Results of a randomized, double-blind, placebo-controlled study. The Journal of Rheumatology. ,vol. 31, pp. 565- 572 ,(2004)
Sherine E. Gabriel, Risk for Serious Gastrointestinal Complications Related to Use of Nonsteroidal Anti-inflammatory Drugs Annals of Internal Medicine. ,vol. 115, pp. 787- 796 ,(1991) , 10.7326/0003-4819-115-10-787
M. Michael Wolfe, David R. Lichtenstein, Gurkirpal Singh, Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs. The New England Journal of Medicine. ,vol. 340, pp. 1888- 1899 ,(1999) , 10.1056/NEJM199906173402407
Diane Dixon, Beth Pollard, Marie Johnston, What does the chronic pain grade questionnaire measure Pain. ,vol. 130, pp. 249- 253 ,(2007) , 10.1016/J.PAIN.2006.12.004
Reva C. Lawrence, Charles G. Helmick, Frank C. Arnett, Richard A. Deyo, David T. Felson, Edward H. Giannini, Stephen P. Heyse, Rosemarie Hirsch, Marc C. Hochberg, Gene G. Hunder, Matthew H. Liang, Stanley R. Pillemer, Virginia D. Steen, Frederick Wolfe, Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States Arthritis & Rheumatism. ,vol. 41, pp. 778- 799 ,(1998) , 10.1002/1529-0131(199805)41:5<778::AID-ART4>3.0.CO;2-V