Involvement of CDKN2 (p16INK4A/MTS1) and p15INK4B/MTS2 in Human Leukemias and Lymphomas

摘要: CDKN2 ( p16INK4A/MTS1 ) and p15INK4B/MTS2 have been shown recently to be potent inhibitors of the cyclin D/cyclin-dependent kinase 4 complex. Both genes are candidates for putative tumor suppressor gene located at chromosome 9p21. We examined a series 14 hematopoietic cell lines 117 primary lymphoid tumors deletion mutation these genes. The included 65 T-cell malignancies 52 B-cell malignancies. line study revealed T-ALL homozygous deletions . Two also showed MTS2 , while remaining 2 retained both alleles. In tumors, were found in 35% T-ALL/lymphoblastic lymphoma (8 23). Homozygous occurred 1 3 precursor B-ALLs. PCR-single strand conformational polymorphism analysis exons exon failed demonstrate mutations either or any T- malignancies, with two possible exceptions. These results consistent role and/or pathogenesis some leukemia/lymphomas, particularly lymphoma.