Effects of NIDDM on Vascular Tone Regulation

摘要: The maintenance of vascular tone is extremely complex. Neural, endocrine, paracrine, and mechanical depressor pressor forces all participate in a delicate balancing act to regulate tone. purpose this chapter review the effect noninsulin-dependent diabetes mellitus (NIDDM) on regulation humans. This issue great clinical importance because NIDDM associated with an increased risk for hypertension macrovascular disease, thus major contributing factor both cardiovascular morbidity mortality (1). Importantly, pattern disease patients cannot be completely attributed either height blood pressure elevation or quantitative qualitative abnormalities circulating lipoprotein particles, suggesting that other factors, such as wall integrity, might play important role (1,2). characterized by insulin resistance, abnormal secretion, hyperglycemia (3). Because secretion are not likely direct vasculature, these will discussed. In contrast, resistance potentially critical factors dysregulation NIDDM, therefore, their effects vasculature discussed some detail. common phenotype usually accompanied obesity. Therefore, special attention paid obesity per se Finally, biology organ- tissue-specific, controlling coronary vessels may different than those peripheral vessels. greatest body knowledge area has been garnered limb arteries, discussion therefore largely focus