Structure-activity relationships of airway irritating aliphatic amines. Receptor activation mechanisms and predicted industrial exposure limits

摘要: Abstract Sensory irritation due to inhalation of diethyl-, triethyl-, dibutyl-, tributyl- and cyclohexylamine was estimated from the decrease in respiratory rate normal mice (American Standard Method E981-84). The concentration-effect relations followed Michaelis-Menten equations, except for diethylamine, which a threshold found. concentrations depressing by 50% (RD 50 ) dibutyl- were 184, 186, 81 27 ppm, respectively. For tributylamine maximum response too low achieve RD value. Pulmonary tracheal-cannulated mice. respective (tRD 549, 691, 101, 96 78 ppm cyclohexylamine. Only minor or no effects on tidal volumes found at lower exposure concentrations. trigeminal pulmonary receptors are believed be activated directly amines, receptor environments lipophilic. Structure-activity analysis made comparing amines with previously investigated primary n -alkylamines. Occupational limits (TLV) both effects. Finally, sensory effect an important part odour sensation, also below TLVs.