Predisposition to urinary tract epithelial metaplasia in Schistosoma haematobium infection.

摘要: Although there is strong epidemiologic evidence linking Schistosoma haematobium infection with carcinoma of the bladder, utility cytologic screening for urinary tract cancer has not been critically evaluated in S. haematobium-endemic populations. The present cross-sectional study examined urine cytology findings among 1,014 residents (ages 1 to 91) Msambweni area Coast Province, Kenya. Among 705 evaluable specimens, prevalence inflammation (39%), hyperkeratosis (30%), metaplasia (33%), and frank atypia (0.4%) was notably higher than previously studied, non-endemic Overall, strongly associated increased risk abnormality (> 2.8-fold relative or hyperkeratosis; P = 60 years old. No cancers were detected population either on follow-up ultrasound examination. These data suggest an age-dependent progression cellular abnormalities epithelium that chronic infection, which becomes independent concurrent intensity as subjects grow older. Implications are discussed.