Serum adiponectin is associated with high-density lipoprotein cholesterol, triglycerides, and low-density lipoprotein particle size in young healthy men.

摘要: The chromosomal localization of adiponectin has been found to be mapped human chromosome 1q21.4-1q23, a region that was identified as susceptibility locus for familial combined hyperlipidemia and polygenic type 2 diabetes. As these disorders are associated with low high-density lipoprotein (HDL)-cholesterol, high triglycerides, insulin resistance (IR), we examined the relation serum concentrations lipid profiles well IR in young healthy men. Serum levels were positively HDL-cholesterol, apolipoprotein (apo) A1, low-density (LDL) particle size, negatively triglycerides apo B. Negative associations also between body mass index (BMI), percent fat, IR,as determined by homeostasis model assessment (HOMA). However, after adjustment BMI, no significant LDL size In multiple regression analysis including all variables showed univariate adiponectin, HDL-cholesterol (beta = 0.079, P =.0009), fat -0.165, =.002), leptin -0.291, =.01) statistically significant. 0.077, =.001), -0.078, =.03), 0.092, =.03) emerged independent determinants HOMA IR, fasting glucose, systolic blood pressure (BP) taken into account. Together, explained 19% variability models. did not emerge determinant both These findings suggest men hypoadiponectinemia is more closely related adiposity dyslipidemia than IR.