Areas of emerging interest in analgesia: cardiovascular complications.

摘要: Many people obtain symptomatic relief from acute, chronic, or recurring pain conditions by using an over-the-counter analgesic. As with the use of any drug, this involves achieving appropriate balance between potential benefit and risk harm. The adverse effects aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) in gastrointestinal (GI) tract are widely appreciated. On basis their pharmacology, however, these also have for causing cardiovascular system. This is particularly case certain overlapping populations (eg, elderly those cardiac failure, hypertension, renal impairment). And size exposed fact they comprise likely to require management because concomitant illnesses make implications analgesic potentially a more serious issue public health than recognized GI complications NSAID use. article discusses impact on system different classes analgesics (NSAIDs, new cyclooxygenase-2-selective inhibitors [CSIs], paracetamol) terms function, thrombotic cardioprotective potential, hypertension. It identifies patients at analgesic-related events, considers options managing mild-to-moderate pain. Unlike that NSAIDs CSIs, pharmacology paracetamol provides no signal should, therefore, be considered as first-line therapy disease.