Virulence factors of Candida albicans

摘要: Candidiasis is a common infection of the skin, oral cavity and esophagus, gastrointestinal tract, vagina vascular system humans. Although most infections occur in patients who are immunocompromised or debilitated some other way, organism often responsible for disease, Candida albicans, expresses several virulence factors that contribute to pathogenesis. These include host recognition biomolecules (adhesins), morphogenesis (the reversible transition between unicellular yeast cells filamentous, growth forms), secreted aspartyl proteases phospholipases. Additionally, 'phenotypic switching' accompanied by changes antigen expression, colony morphology tissue affinities C. albicans spp. Switching might provide with flexibility results adaptation hostile conditions imposed not only but also physician treating infection.