New CeF3-ZnO nanocomposites for self-lighted photodynamic therapy that block adenocarcinoma cell life cycle.
作者： Davide Orsi , Tiziano Rimoldi , Silvana Pinelli , Rossella Alinovi , Matteo Goldoni
关键词:
摘要: Aim To synthesize and characterize the performances of a new all-inorganic nanocomposite (NC) for self-lighted photodynamic therapy against cancer. This NC could allow radiotherapy doses to be reduced, as it enhances effects x-rays, generating cytotoxic reactive oxygen species singlet oxygen. Materials & methods The proposed combines CeF3 ZnO; absorbs 6-MeV x-rays activates photosensitizer ZnO. Characterization is performed by transmission electron microscopy (TEM), scanning-TEM, energy dispersive x-ray spectrometry fluorescence spectroscopies. Efficiency on human adenocarcinoma cells (A549) was tested spectroscopy, cytofluorimetry, viability assays, clonogenic cell cycle progression assays. Results blocks A549's before mitosis in dark. Upon low-dose irradiation (2 Gy), species/singlet are generated, further blocking reducing 18% with respect sum dark activity. Conclusion These novel NCs promise reduce radiotherapy, helping unwanted side effects.
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