Advances in Biomimetic Apatite Coating on Metal Implants

摘要: Artificial implants are generally encapsulated by a fibrous tissue when implanted into bone defects. However, Hench et al. showed that bioglass directly bonded to living via biologically active bone-like apatite layer instead of the formation surrounding tissue(Hench al., 1971). Meanwhile, with mineral compositional resemblance inorganic phase human bone, calcium phosphate ceramics possessed excellent biocompatibility and osteoconductivity, it also bone-bonding ability layer(W.P. Cao & Hench, 1996; 1998). Nowadays, they both extensively used as hard repair or substitution materials in clinic. these cannot be under load-bearing conditions such femur, tibia spinal interbody, because usually very stiff brittle, have low impact resistance relatively tensile strength(Rezwan 2006). Titanium its alloys widely orthopaedic due their superior mechanical properties biocompatibility( X.Y. Liu 2004; Ratner, 2001). bioactivity not good during implantation can only form osteointegration at interface titanium tissue, bone-bonding(Feng 2002). To overcome disadvantages, various methods coating surface been developed combine metals bioactive ceramics, ion-beam(Ong 1992) radiofrequency magnetron sputter deposition(Wolke 1998), sol–gel method (Brendel 1992; Weng Baptista, 1999) al, plasma spraying being most popular(Y. J. Chen 1994). each them has own technical limitations, for example, inability coat those complex-shaped internal cavities porous incorporate agents. Therefore, an optimal technique coatings on still developed. One alternative is so-called biomimetic coating, which consists mimicking mineralization process immersing simulated body fluid (SBF) mimics composition, pH, temperature blood plasma(Abe 1990). As result this technique, diverse Ca-P phases amorphous (ACP), octacalcium (OCP) carbonated (CA), some stable temperatures,