The emulsified perfluorocarbon Oxycyte improves spinal cord injury in a swine model of decompression sickness.

摘要: A prospective, animal model for pharmacological intervention of decompression sickness (DCS), including spinal cord (SC) injury. Signs and symptoms DCS can include joint pain, skin discoloration, cardiopulmonary congestion SC injury; severity ranges from trivial to fatal. Non-recompressive therapy may improve time-to-treatment therefore impact mortality morbidity. Oxycyte at 5 cc kg−1 provides both protection statistically significant survival benefit in a swine DCS. The purpose this study was test whether reduced dose (3 cc kg−1) would provide similar benefit. Silver Spring, MD, USA Male Yorkshire (N=50) underwent non-linear compression profile 200 fsw (feet sea water), which identical previous work using the Oxycyte. After 31 min bottom time, initiated 30 fsw per minute until surface pressure reached. Following onset DCS, intravenous or saline administered with concurrent 100% O2 1 h. primary end point DCS-induced mortality, Tarlov score histopathology as secondary points. administration 3 cc kg−1 following surfacing produced no detectable Animals that received Oxycyte, however, had lesion area. Further studies determine lowest fully efficacious adjunct treatment are warranted.