Naltrexone-Induced Alterations in Human Ethanol Intoxication

摘要: Objective: Outpatient clinical trials with an opioid antagonist, naltrexone, found that this agent reduces relapse drinking in abstinent alcoholics. It is unknown which aspects of intoxication may be affected by naltrexone. The authors investigated the effects naltrexone on several subjective and objective measures ethanol intoxication. Method: In a double-blind crossover study, 1 9 nonalcoholic drinkers received regimen 50 mg p.o., or placebo two different occasions, each time followed standard, intoxicating dose ethanol. Subjective including mood, physical sensations, performance changes, pharmacokinetics were. determined. As control for effects, 12 additional subjects nonintoxicating, “placebo” ofethanol. Results: Naltrexone augmented certain sedative discriminant ofethanol reduced positive reinforcing without affecting psychomotor pharmacokinetics. had minimal receiving Conclusions: data are compatible findings suggest reduction consumption alcoholics following administration occur because ofgreater intoxication, greater aversive less reinforcement from (Am J Psychiatry 1994; 151:1463-1467)