Platelet transfusions in neonates: practices in the United States vary significantly from those in Austria, Germany, and Switzerland.

摘要: BACKGROUND: Thrombocytopenia affects 20% to 35% of patients admitted neonatal intensive care units (NICUs). Platelet (PLT) transfusions are usually administered neonates with thrombocytopenia at higher thresholds than those used for older children or adults, although there is a paucity evidence guide these decisions. STUDY DESIGN AND METHODS: In this study, we Web-based survey investigate the PLT transfusion in Level 1 NICUs (equivalent 3 US) three European countries (Austria, Germany, and Switzerland [AUT/GER/SUI]). This was identical one that previously sent US neonatologists, thus allowing direct comparison their responses 11 case-based scenarios. RESULTS: nine scenarios, AUT/GER/SUI neonatologists selected substantially lower (p < 0.0001). Transfusion were more similar when treating alloimmune before invasive procedures. The clinical impact differences estimated by extrapolating versus answers cohort birth weight below 1000 g. suggested that, AUT/GER/SUI, would receive 167 per 1000 infants, compared 299 United States. CONCLUSION: first international comparative on practice reveals States AUT/GER/SUI. Well-designed studies needed address risks and/or benefits different approaches.