Genetic Variations in Nrf2-Keap1 Complex: A Step towards Understanding Cancer Resistance in Blind Mole Rats Cytotypes
作者： Dilara Fatma Akın-Balı , Teoman Kankılıç
DOI: 10.1134/S1062359019060050
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摘要: Abstract—The Nrf2-Keap1 regulation system plays a crucial role in cytoprotection against electrophilic/oxidative stress. Previous studies have identified missense mutations Nrf2/Keap1 complex which abolish its activity. The amino acid corresponding to codon 212 Keapl’s IVR domain is conserved as tyrosine (Y) among different mammalian species whereas only Nannospalax and two other carry cysteine (C) residue at this position. These include Sperm whale European hedgehog that live hypoxic environment. In study, we examined genetic variations complex, was reported be important cancer pathogenesis previous studies, resistant blind mole rat with varying chromosome numbers (2n: 46–60) collected from regions Turkey. This study the first provide information on variants of rats living
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