Human chorionic gonadotropin in cancer

摘要: Abstract Human chorionic gonadotropin (hCG) is mainly used for detection and monitoring of pregnancy pregnancy-related disorders but it also an extremely sensitive specific marker trophoblastic tumors placental germ cell origin. Thus treatment relapsing choriocarcinomas testicular often initiated on the basis rising hCG levels even in absence clinical or histological evidence a relapse. While these mostly produce intact heterodimeric hormone consisting α (hCGα), β subunit (hCGβ), many nontrophoblastic only hCGβ This usually sign aggressive disease elevated serum are strongly associated with poor prognosis. Elevated observed 45–60% patients biliary pancreatic cancer 10–30% most other cancers. Methods that detect together measurement hCG-like immunoreactivity serum. However, reference range 5–8 fold higher than thus moderately can be identified assay.