Magnetic resonance imaging of CNS in 15,043 children with GH deficiency in KIGS (Pfizer International Growth Database)

摘要: Objectives: Neuroimaging has become an essential part of the diagnostic process in children with GH deficiency (GHD). The aim study was to document frequency neuroanatomical abnormalities a very large cohort GHD and relate these findings patient clinical characteristics. Design methods: Results magnetic resonance imaging (MRI) were reported 15 043 43 725 non-acquired (idiopathic, neurosecretory dysfunction (NSD) known congenital cause) who enrolled KIGS (Pfizer International Growth Database) between 1987 2011. Clinical characteristics patients before treatment normal MRI (idiopathic (IGHD) NSD) compared those abnormal pituitaries (hypoplasia, empty sella (ES), HME (hypoplastic anterior pituitary, missing pituitary stalk ectopic posterior pituitary)). Results: Abnormal MRIs found 4032 (26.8%) children, within which ES (nZ1178 (7.8%)) (nZ1019 (6.8%)) most frequent findings. In 2361 diagnosed as IGHD or NSD examination, anatomical ((pituitary hypoplasia: nZ974); (HME: nZ459)) documented. Patients had more severe GHD: ! hypoplasia HME. Conclusions: is associated great variety identified by MRI. investigation evaluation need be conducted structured mode. There association functional pituitary.