Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer.
作者： Peter W Stacpoole
DOI: 10.1093/JNCI/DJX071
关键词:
摘要: … complex (PDC). Many of the calories we consume daily pass through the PDC, which, under … The PDC and acyl CoA carboxylase, which initiates the beta-oxidation pathway of long-…
oup.com
sci-hub.se 参考文章(173)
Robert Haas, Joanne Smith, Vidalba Rocher-Ros, Suchita Nadkarni, Trinidad Montero-Melendez, Fulvio D’Acquisto, Elliot J. Bland, Michele Bombardieri, Costantino Pitzalis, Mauro Perretti, Federica M. Marelli-Berg, Claudio Mauro, Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions PLOS Biology. ,vol. 13, pp. e1002202- ,(2015) , 10.1371/JOURNAL.PBIO.1002202
Weiguo Feng, Andrew Gentles, Ramesh V. Nair, Min Huang, Yuan Lin, Cleo Y. Lee, Shang Cai, Ferenc A. Scheeren, Angera H. Kuo, Maximilian Diehn, Targeting unique metabolic properties of breast tumor initiating cells Stem Cells. ,vol. 32, pp. 1734- 1745 ,(2014) , 10.1002/STEM.1662
Jae Mo Park, Sonal Josan, Taichang Jang, Milton Merchant, Ron Watkins, Ralph E. Hurd, Lawrence D. Recht, Dirk Mayer, Daniel M. Spielman, Volumetric spiral chemical shift imaging of hyperpolarized [2‐13c]pyruvate in a rat c6 glioma model Magnetic Resonance in Medicine. ,vol. 75, pp. 973- 984 ,(2016) , 10.1002/MRM.25766
Peter W. Stacpoole, The pyruvate dehydrogenase complex as a therapeutic target for age-related diseases. Aging Cell. ,vol. 11, pp. 371- 377 ,(2012) , 10.1111/J.1474-9726.2012.00805.X
Toshimitsu Ohashi, Takashi Akazawa, Mitsuhiro Aoki, Bunya Kuze, Keisuke Mizuta, Yatsuji Ito, Norimitsu Inoue, Dichloroacetate improves immune dysfunction caused by tumor-secreted lactic acid and increases antitumor immunoreactivity. International Journal of Cancer. ,vol. 133, pp. 1107- 1118 ,(2013) , 10.1002/IJC.28114
Alessandro Prigione, Nadine Rohwer, Sheila Hoffmann, Barbara Mlody, Katharina Drews, Raul Bukowiecki, Katharina Blümlein, Erich E. Wanker, Markus Ralser, Thorsten Cramer, James Adjaye, HIF1α Modulates Cell Fate Reprogramming Through Early Glycolytic Shift and Upregulation of PDK1–3 and PKM2 Stem Cells. ,vol. 32, pp. 364- 376 ,(2014) , 10.1002/STEM.1552
Sue Whitehouse, Ronald H. Cooper, Philip J. Randle, Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids Biochemical Journal. ,vol. 141, pp. 761- 774 ,(1974) , 10.1042/BJ1410761
Chunyan Li, Gang Meng, Lei Su, Aiping Chen, Mao Xia, Chun Xu, Decai Yu, Aiqin Jiang, Jiwu Wei, Dichloroacetate blocks aerobic glycolytic adaptation to attenuated measles virus and promotes viral replication leading to enhanced oncolysis in glioblastoma. Oncotarget. ,vol. 6, pp. 1544- 1555 ,(2015) , 10.18632/ONCOTARGET.2838
Ana Sofia Rodrigues, Marcelo Correia, Andreia Gomes, Sandro L. Pereira, Tânia Perestrelo, Maria Inês Sousa, João Ramalho-Santos, Dichloroacetate, the Pyruvate Dehydrogenase Complex and the Modulation of mESC Pluripotency PLOS ONE. ,vol. 10, pp. e0131663- ,(2015) , 10.1371/JOURNAL.PONE.0131663
Melissa M. BOWKER-KINLEY, I. Wilhelmina DAVIS, Pengfei WU, A. Robert HARRIS, M. Kirill POPOV, Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex Biochemical Journal. ,vol. 329, pp. 191- 196 ,(1998) , 10.1042/BJ3290191