Magnetoliposomes with size controllable insertion of magnetic nanoparticles for efficient targeting of cancer cells

摘要: Liposomes with embedded magnetic nanoparticles (magnetoliposomes; MLs) are promising nano-platforms for various biomedical applications. The behavior of MLs depends on the size (MNPs); in general, larger MNPs more advantageous (e.g. increased signals). However, insertion large into liposome bilayers is constrained by thickness membrane (∼3.4 nm); thus, incorporation (>3.4 nm) liposomes a major challenge. We developed solvent-guided approach simple and efficient (6 nm or 15 liposomal bilayer. 6 were used field-guided separation cancer cells targeting to human epidermal receptor 2 folate receptor. also evaluated nuclear delivery oligonucleotides cationic lipid formula. expected be versatile applications disease diagnosis, therapeutics cell tracking).