Precision Medicine in Hematology 2021: Definitions, Tools, Perspectives, and Open Questions.

摘要: During the past few years, our understanding of molecular mechanisms and cellular interactions relevant to malignant blood cell disorders has improved substantially. New insights include a detailed knowledge about disease-initiating exogenous factors, endogenous (genetic, somatic, epigenetic) elicitors or facilitators disease evolution, drug actions that underlie efficacy adverse event profiles in defined cohorts patients. As result, precision medicine personalized are rapidly growing new disciplines support clinician making correct diagnosis, predicting outcomes, optimally selecting patients for interventional therapies. In addition, tools greatly facilitating development drugs, therapeutic approaches, multiparametric prognostic scoring models. However, although emerging roles hematology oncology clearly visible, several questions remain. For example, it remains unknown how can be implemented healthcare systems whether all possible approaches also affordable. there is need define terminologies relate these specific context-related strategies basic applied science. To discuss issues, working conference was organized September 2019. The outcomes this summarized herein proposal definitions, terminologies, applications concepts hematologic neoplasms. We provide proposals aimed at reducing costs, thereby affordable daily practice.