Electrospun nano- to microfiber fabrics made of biodegradable copolyesters: structural characteristics, mechanical properties and cell adhesion potential

摘要: Nano- to micro-structured biodegradable poly(L-lactide-co-epsilon-caprolactone) (PLCL) fabrics were prepared by electrospinning. Electrospun microfiber with different compositions of PLCL (mol% in feed; 70/30, 50/50, and 30/70), poly(L-lactide) (PLL) poly(epsilon-caprolactone) (PCL) obtained using methylene chloride (MC) as a solvent. The PLL exhibited nanoscale-pore structure pore diameter approximately 200-800 nm at the surface subsurface regions, whereas such was hardly observed other polymers containing CL. fabric made 50/50 elastomeric. Nanoscale-fiber (approx. 0.3 or 1.2 microm diameter) electrospun 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) Mercury porosimetry showed that decrease fiber decreased porosity, but increased density mechanical strength. Human umbilical vein endothelial cells (HUVECs) adhered well proliferated on small-diameter-fiber (0.3 diameter), both which are dense fabrics, markedly reduced cell adhesion, restricted spreading no signs proliferation large-diameter-fiber (7.0 diameter). potential biomedical application discussed.