HLA-G polymorphisms in African Americans.

摘要: HLA-G is a class I MHC gene most notable for its restricted tissue distribution. The unique expression of this in extravillous cytotrophoblast at the maternal-fetal interface suggests that plays critical role human pregnancy. Previous studies have reported has limited repertoire rare alleles, unlike classical which are among polymorphic genes. To determine full extent sequence variation gene, we examined nucleotide first six exons 45 healthy African American persons. By using sensitive techniques detect > 95% substitutions, detected two variations alpha-1 domain (exon 2) and 24 alpha-2 3) result amino acid substitutions. These data indicate potentially capable presenting wide variety peptides eliciting an allogeneic response, similar to HLA