Hydroxyapatite fiber reinforced poly(α-hydroxy ester) foams for bone regeneration

摘要: A process has been developed to manufacture biodegradable composite foams of poly(DL-lactic-co-glycolic acid) (PLGA) and hydroxyapatite short fibers for use in bone regeneration. The processing technique allows the three-dimensional foam scaffolds involves formation a material consisting porogen (either gelatin microspheres or salt particles) embedded PLGA matrix. After is leached out, an open-cell remains which pore size morphology defined by porogen. By changing weight fraction leachable component it was possible produce with controlled porosities ranging from 0.47 +/- 0.02 0.85 0.01 (n = 3). Up polymer:fiber ratio 7:6, served reinforce low-porosity manufactured using as Foams compressive yield strength up 2.82 0.63 MPa 3) porosity were 7:6. In contrast, high-porosity (up 0.81 0.02, n suitable cell seeding not reinforced introduction increasing quantities fibers. We therefore able may be seeded cells but have minimal strength, low enhanced osteoconductivity strength.