Sipa1l3/SPAR3 is targeted to postsynaptic specializations and interacts with the Fezzin ProSAPiP1/Lzts3
作者： Anna Dolnik , Noreen Kanwal , Sarah Mackert , Sonja Halbedl , Christian Proepper
DOI: 10.1111/JNC.13353
关键词:
摘要: Rap GTPase-activating proteins (RapGAPs) are essential for synaptic function as they tightly regulate signaling. Among the most abundant RapGAPs in brain Spine-associated (SPARs) Sipa1l1/SPAR and Sipa1l2/SPAR2, whereas nothing has been reported on Sipa1l3/SPAR3. In this study, we show that Sipa1l3/SPAR3 is conserved across species, a distinct expression pattern developing rat localized at excitatory postsynapses. We further demonstrate C-terminus required postsynaptic targeting represents an interaction module Fezzins such ProSAPiP1/Lzts3, binding partner of scaffold protein Shank3. Taken together, our data imply hitherto unknown RapGAP, which targeted to specializations interacts with Fezzins. modulators Our study first characterize SPAR family member neuronal tissue. postsynapses via its C-terminus, other including Fezzin ProSAPiP1/Lzts3.
sci-hub.se 参考文章(26)
Christina Spilker, Michael R. Kreutz, RapGAPs in brain: multipurpose players in neuronal Rap signalling. European Journal of Neuroscience. ,vol. 32, pp. 1- 9 ,(2010) , 10.1111/J.1460-9568.2010.07273.X
Stefan Liebau, Julie Steinestel, Leonhard Linta, Alexander Kleger, Alexander Storch, Michael Schoen, Konrad Steinestel, Christian Proepper, Juergen Bockmann, Michael J. Schmeisser, Tobias M. Boeckers, An SK3 Channel/nWASP/Abi-1 Complex Is Involved in Early Neurogenesis PLoS ONE. ,vol. 6, pp. e18148- ,(2011) , 10.1371/JOURNAL.PONE.0018148
Badal C. Roy, Kazuyoshi Kohu, Ken Matsuura, Hiroyuki Yanai, Tetsu Akiyama, SPAL, a Rap-specific GTPase activating protein, is present in the NMDA receptor-PSD-95 complex in the hippocampus Genes to Cells. ,vol. 7, pp. 607- 617 ,(2002) , 10.1046/J.1365-2443.2002.00546.X
Ying Chen, Pingan Yuanxiang, Thomas Knöpfel, Ulrich Thomas, Thomas Behnisch, Hippocampal LTP triggers proteasome-mediated SPAR degradation in CA1 neurons. Synapse. ,vol. 66, pp. 142- 150 ,(2012) , 10.1002/SYN.20994
Michael J. Schmeisser, Andreas M. Grabrucker, Juergen Bockmann, Tobias M. Boeckers, Synaptic Cross-talk betweenN-Methyl-d-aspartate Receptors and LAPSER1-β-Catenin at Excitatory Synapses Journal of Biological Chemistry. ,vol. 284, pp. 29146- 29157 ,(2009) , 10.1074/JBC.M109.020628
Daniela M Cochoy, Alexander Kolevzon, Yuji Kajiwara, Michael Schoen, Maria Pascual-Lucas, Stacey Lurie, Joseph D Buxbaum, Tobias M Boeckers, Michael J Schmeisser, Phenotypic and functional analysis of SHANK3 stop mutations identified in individuals with ASD and/or ID. Molecular Autism. ,vol. 6, pp. 23- 23 ,(2015) , 10.1186/S13229-015-0020-5
Andreas M. Grabrucker, Michael J. Schmeisser, Michael Schoen, Tobias M. Boeckers, Postsynaptic ProSAP/Shank scaffolds in the cross-hair of synaptopathies. Trends in Cell Biology. ,vol. 21, pp. 594- 603 ,(2011) , 10.1016/J.TCB.2011.07.003
Scott Herrick, Danielle M. Evers, Ji-Yun Lee, Noriko Udagawa, Daniel T.S. Pak, Postsynaptic PDLIM5/Enigma Homolog binds SPAR and causes dendritic spine shrinkage Molecular and Cellular Neuroscience. ,vol. 43, pp. 188- 200 ,(2010) , 10.1016/J.MCN.2009.10.009
Michael J. Schmeisser, Translational neurobiology in Shank mutant mice - Model systems for neuropsychiatric disorders Annals of Anatomy-anatomischer Anzeiger. ,vol. 200, pp. 115- 117 ,(2015) , 10.1016/J.AANAT.2015.03.006
Daniel T. S. Pak, Morgan Sheng, Targeted protein degradation and synapse remodeling by an inducible protein kinase. Science. ,vol. 302, pp. 1368- 1373 ,(2003) , 10.1126/SCIENCE.1082475