Conjugated linoleic acids: why the discrepancy between animal and human studies?

摘要: Conjugated linoleic acids (CLA) are positional and geometric isomers of acid. In animals, CLA consumption reduces body fat but results in humans less conclusive. This review the literature on loss or weight was conducted to explore reasons for discrepancy between animal clinical trials. It indicates that incongruity human data is largely related methodological differences experimental design, including age gender and, a lesser extent, dose isomers. The relatively unknown metabolic fate may also be contributing factor helps explain lack consistency efficacy across studies.