Surface characterization of collagen/elastin based biomaterials for tissue regeneration

摘要: Abstract Collagen and elastin are the main proteins of extracellular matrix. plays a crucial role in tensile strength tissues, whereas provides resilience to many organs. Both biopolymers readily available biocompatible. These properties point out that collagen good components materials for potential medical applications. The surface biomaterials play an important biomedicine as majority biological reactions occur on implanted materials. One methods modification is UV-irradiation. exposition biomaterial ultraviolet light can alterate materials, their chemical stability, swelling mechanical well. aim our work was study biocompatibility new collagen/elastin based consideration influence these properties. modified by UV-irradiation were studied using technique atomic force microscopy (AFM) contact angle measurements. On basis results free energy its polar component calculated Owens–Wendt method. To assess performance films collagen, blends, response 3T3 cell investigated. It found film enriched less – collagen. Exposition UV increases polarity films, due photooxidation process. AFM images have shown topography roughness had been also affected changes interaction between material's cells. investigation cells grown leads conclusion higher content promotes adhesion viability surface. Also suitable dose (1, 2 h) improves